rs10510057 - RGS10 - TIAL1
Magnitude 2.2 · 1 study on file
Reported associations
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The First Pilot Genome-Wide Gene-Environment Study of Depression in the Japanese Population - Unknown journal (n.d.) · Unknown authors · PubMed 27529621
ABSTRACT: Stressful events have been identified as a risk factor for depression. Although gene-environment (G × E) interaction in a limited number of candidate genes has been explored, no genome-wide search has been reported. The aim of the present study is to identify genes that influence the association of stressful events with depression. Therefore, we performed a genome-wide G × E interaction analysis in the Japanese population. A genome-wide screen with 320 subjects was performed using the Affymetrix Genome-Wide Human Array 6.0. Stressful life events were assessed using the Social Readjustment Rating Scale (SRRS) and depression symptoms were assessed with self-rating questionnaires using the Center for Epidemiologic Studies Depression (CES-D) scale. The p values for interactions b
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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depression screening and preventive counseling Moderate
rs10510057 C/C genotype confers susceptibility to depression during stressful periods
Lifestyle
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stress management and mental resilience practices Moderate
rs10510057 C allele increases depression risk in response to stressful life events through altered RGS10-mediated monoamine signaling
Implement regular stress-management practices such as mindfulness, yoga, or exercise