rs10509852 - LINC01435

Magnitude 2.2 · 1 study on file

Reported associations

• The common variants implicated in microstructural abnormality of first episode and drug-naïve patients with schizophrenia - Unknown journal (n.d.) · Unknown authors · PubMed 28924203

  ABSTRACT: Both post-mortem and neuroimaging studies have identified abnormal white matter (WM) microstructure in patients with schizophrenia. However, its genetic underpinnings and relevant biological pathways remain unclear. In order to unravel the genes and the pathways associated with abnormal WM microstructure in schizophrenia, we recruited 100 first-episode, drug-naïve patients with schizophrenia and 140 matched healthy controls to conduct genome-wide association analysis of fractional anisotropy (FA) value measured using diffusing tensor imaging (DTI), followed by multivariate association study and pathway enrichment analysis. The results showed that one intergenic SNP (rs11901793), which is 20 kb upstream of CXCR7 gene on chromosome 2, was associated with the total mean FA values

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