Expressive

rs10509768 - SH3PXD2A

Magnitude 2.8 · 1 study on file

Reported associations

  • Ethnic similarities in genetic polymorphisms associated with atrial fibrillation: Far East Asian vs European populations. - European journal of clinical investigation (2022) · Hong M, Ebana Y, Shim J, Choi EK, Lim HE, Hwang I, Yu HT, Kim TH, Uhm JS, Joung B, Oh S, Lee MH, Kim YH, Jee SH, Pak HN · PubMed 33990960

    In European ancestry, 111 genetic loci were identified as associated with atrial fibrillation (AF). We explored the reproducibility of those single nucleotide polymorphisms (SNPs) in a genome-wide association study (GWAS) meta-analysis of Far East Asian populations. We performed a meta-analysis of the Korean AF network and Japanese AF data sets (9118 cases and 33 467 controls) by an inverse-variance fixed-effects model. We compared the results with 111 previously reported SNPs proven in Europeans after excluding 36 missing loci and a locus with a minor allelic frequency (MAF) < 0.01 in the European population. Among remaining 74 loci, 29 loci were replicated at a P < .05, and 17 of those loci were newly found in the Far East Asian population: 3 loci with a P < 5×10 (METTL11B at 1q2

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • atrial fibrillation risk assessment and prevention strategy Moderate

    Variant carriers have 1.2-fold increased AFib risk; risk stratification guides personalized monitoring and prevention approach

Exercise

  • regular aerobic exercise program Moderate

    Aerobic fitness reduces AFib risk through improved cardiac function and decreased inflammatory burden

    150 minutes moderate-intensity aerobic activity weekly; discuss exercise safety with cardiologist before starting

Lifestyle

  • moderate alcohol consumption Moderate

    Alcohol increases AFib risk; moderation reduces risk burden in genetically predisposed carriers

    Limit to maximum 1 drink per day for women, 2 for men; avoid binge drinking

Screening

  • baseline 12-lead electrocardiogram Moderate

    ECG provides baseline rhythm assessment and enables early detection of AFib in genetically predisposed individuals

    Obtain baseline 12-lead ECG; discuss appropriate monitoring interval with physician

  • blood pressure monitoring and control Moderate

    Hypertension is a major modifiable AFib risk factor; control is particularly important in genetic predisposition

    Monitor BP at each visit; target <130/80 mmHg per current guidelines; treat hypertension if present