Expressive

rs10508774 - CCDC7

Magnitude 4.5 · 1 study on file

Reported associations

  • Genetic Variants in the Bone Morphogenic Protein Gene Family Modify the Association between Residential Exposure to Traffic and Peripheral Arterial Disease. - PloS one (2016) · Ward-Caviness CK, Neas LM, Blach C, Haynes CS, LaRocque-Abramson K, Grass E, Dowdy E, Devlin RB, Diaz-Sanchez D, Cascio WE, Lynn Miranda M, Gregory SG, Shah SH, Kraus WE, Hauser ER · PubMed 27082954

    There is a growing literature indicating that genetic variants modify many of the associations between environmental exposures and clinical outcomes, potentially by increasing susceptibility to these exposures. However, genome-scale investigations of these interactions have been rarely performed particularly in the case of air pollution exposures. We performed race-stratified genome-wide gene-environment interaction association studies on European-American (EA, N = 1623) and African-American (AA, N = 554) cohorts to investigate the joint influence of common single nucleotide polymorphisms (SNPs) and residential exposure to traffic ("traffic exposure")-a recognized vascular disease risk factor-on peripheral arterial disease (PAD). Traffic exposure was estimated via the distance from the pri

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Lifestyle

  • traffic-related air pollution exposure Moderate

    Rs10508774 interacts with traffic-related air pollution to elevate peripheral arterial disease risk in carriers.

    minimize time in heavy traffic; use real-time air quality monitoring; maintain vehicle air filtration

Screening

  • peripheral arterial disease assessment Moderate

    Rs10508774 carriers show elevated PAD risk, particularly in high air pollution exposure contexts, suggesting baseline vascular disease screening may be warranted.

    discuss ankle-brachial index screening with primary care, especially in high-pollution areas