rs10508372 - LINC02676

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population - Unknown journal (n.d.) · Unknown authors · PubMed 21804548

  [INTRO] Bronchial asthma is a common inflammatory disease caused by the interaction of genetic and environmental factors. Through a genome-wide association study (GWAS) and a replication study consisting of a total of 7,171 subjects with adult asthma and 27,912 controls in the Japanese population, we identified five candidate loci associated with susceptibility to adult asthma. In addition to the major histocompatibility complex (MHC) and TSLP/WDR36 loci reported previously, we identified three additional loci: a USP38/GAB1 locus on chromosome 4q31 (combined P = 1.87 × 10-12), a locus on chromosome 10p14 (P = 1.79 × 10-15) and a gene-rich region on chromosome 12q13 (P = 2.33 × 10-13). The most significant association with adult asthma was observed at rs404860 in the MHC region (P = 4.07

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