rs10508343 - GATA3 - PRPF38AP1

Magnitude 4.5 · 1 study on file

Reported associations

• Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia - Unknown journal (n.d.) · Unknown authors · PubMed 19176441

  ABSTRACT: Context Pediatric acute lymphoblastic leukemia (ALL) is the prototype for a drug-responsive malignancy. Although cure rates exceed 80%, considerable unexplained interindividual variability exists in treatment response. Objective Using a genome-wide approach, to assess the contribution of inherited genetic variation to therapy response and to identify germline single nucleotide polymorphisms (SNPs) associated with risk of minimal residual disease (MRD) after remission induction chemotherapy. Design, Setting, and Patients We performed a genome-wide interrogation of 476,796 germline SNPs to identify genotypes that predicted MRD in two independent cohorts of children with newly diagnosed ALL: 318 patients on St. Jude trials Total XIIIB and XV and 169 patients on a Children's Oncolo

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