rs10508164 - LINC00343

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide association studies and heritability analysis reveal the involvement of host genetics in the Japanese gut microbiota - Unknown journal (n.d.) · Unknown authors · PubMed 33208821

  ABSTRACT: Numerous host extrinsic and intrinsic factors affect the gut microbiota composition, but their cumulative effects do not sufficiently explain the variation in the microbiota, suggesting contributions of missing factors. The Japanese population possesses homogeneous genetic features suitable for genome-wide association study (GWAS). Here, we performed GWASs for human gut microbiota using 1068 healthy Japanese adults. To precisely evaluate genetic effects, we corrected for the impacts of numerous host extrinsic and demographic factors by introducing them as covariates, enabling us to discover five loci significantly associated with microbiome diversity measures: HS3ST4, C2CD2, 2p16.1, 10p15.1, and 18q12.2. Nevertheless, these five variants explain only a small fraction of the varia

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