rs10507577 - RN7SL618P - ZNF646P1

Magnitude 2.0 · 1 study on file

Reported associations

• Genome-wide association with select biomarker traits in the Framingham Heart Study - Unknown journal (n.d.) · Unknown authors · PubMed 17903293

  ABSTRACT: Background Systemic biomarkers provide insights into disease pathogenesis, diagnosis, and risk stratification. Many systemic biomarker concentrations are heritable phenotypes. Genome-wide association studies (GWAS) provide mechanisms to investigate the genetic contributions to biomarker variability unconstrained by current knowledge of physiological relations. Methods We examined the association of Affymetrix 100K GeneChip single nucleotide polymorphisms (SNPs) to 22 systemic biomarker concentrations in 4 biological domains: inflammation/oxidative stress; natriuretic peptides; liver function; and vitamins. Related members of the Framingham Offspring cohort (n = 1012; mean age 59 ± 10 years, 51% women) had both phenotype and genotype data (minimum-maximum per phenotype n = 507-

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