rs10507084 - LINC02409 - RMST

Magnitude 2.2 · 1 study on file

Reported associations

• Genetic analysis of obstructive sleep apnoea discovers a strong association with cardiometabolic health. - The European respiratory journal (2021) · Strausz S, Ruotsalainen S, Ollila HM, Karjalainen J, Kiiskinen T, Reeve M, Kurki M, Mars N, Havulinna AS, Luonsi E, Mansour Aly D, Ahlqvist E, Teder-Laving M, Palta P, Groop L, Mägi R, Mäkitie A, Salomaa V, Bachour A, Tuomi T, Palotie A, Palotie T, Ripatti S · PubMed 33243845

  There is currently limited understanding of the genetic aetiology of obstructive sleep apnoea (OSA). We aimed to identify genetic loci associated with OSA risk, and to test if OSA and its comorbidities share a common genetic background.We conducted the first large-scale genome-wide association study of OSA using the FinnGen study (217 955 individuals) with 16 761 OSA patients identified using nationwide health registries.We estimated 0.08 (95% CI 0.06-0.11) heritability and identified five loci associated with OSA (p<5.0×10 ): rs4837016 near (GTPase activating protein and VPS9 domains 1), rs10928560 near (C-X-C motif chemokine receptor type 4), rs185932673 near (calcium/calmodulin-dependent protein kinase ID) and rs9937053 near (fat mass and obesity-associated protein; a variant previ

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