rs1050528 - ATP1B2
Magnitude 2.2 · 1 study on file
Reported associations
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Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program - Unknown journal (n.d.) · Unknown authors · PubMed 39024449
ABSTRACT: INTRODUCTION: Findings from genome-wide association studies (GWASs) have provided foundational knowledge of the genetic basis of disease, facilitating precision approaches for prevention and treatment. Current GWAS results are limited by underrepresentation of individuals from diverse populations, leading to concerns with generalizability regarding our knowledge of the relationships between genes, traits, and disease. The Department of Veterans Affairs (VA) Million Veteran Program (MVP), one of the largest US-based biobanks, addresses this need; 29% of MVP comprises individuals genetically similar to African (AFR), Admixed American (AMR), and East Asian (EAS) reference populations. With over 635,000 participants and more than 44.3M genotyped variants linked with detailed phenotyp
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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Refined carbohydrates and added sugars Moderate
Refined carbs and sugars increase hepatic triglyceride synthesis; variant carriers with genetic predisposition benefit from reduced intake
Limit refined grains and sugars to less than 10 percent of daily calories
Exercise
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Aerobic exercise for triglyceride reduction Moderate
Aerobic activity increases triglyceride clearance and reduces hepatic VLDL production
150 minutes moderate-intensity aerobic activity per week
Screening
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Triglyceride levels via lipid panel Moderate
ATP1B2 rs1050528 T allele is associated with elevated fasting and mean triglycerides across large populations
Annual lipid panel with fasting triglycerides; more frequent if elevated above 150 mg/dL