Expressive

rs10504754 - HNRNPA1P4 - DPPA3P9

Magnitude 4.5 · 2 studies on file

Reported associations

  • Genome-wide Association Study of Susceptibility to Particulate Matter-Associated QT Prolongation - Unknown journal (n.d.) · Unknown authors · PubMed 28749367

    ABSTRACT: Background: Ambient particulate matter (PM) air pollution exposure has been associated with increases in QT interval duration (QT). However, innate susceptibility to PM-associated QT prolongation has not been characterized. Objective: To characterize genetic susceptibility to PM-associated QT prolongation in a multi-racial/ethnic, genome-wide association study (GWAS). Methods: Using repeated electrocardiograms (1986-2004), longitudinal data on in diameter (), and generalized estimating equations methods adapted for low-prevalence exposure, we estimated approximately interactions among nine Women's Health Initiative clinical trials and Atherosclerosis Risk in Communities Study subpopulations (), then combined subpopulation-specific results in a fixed-effects, inverse varian

  • Comprehensive genomic analysis of dietary habits in UK Biobank identifies hundreds of genetic associations - Unknown journal (n.d.) · Unknown authors · PubMed 32193382

    ABSTRACT: Unhealthful dietary habits are leading risk factors for life-altering diseases and mortality. Large-scale biobanks now enable genetic analysis of traits with modest heritability, such as diet. We perform a genomewide association on 85 single food intake and 85 principal component-derived dietary patterns from food frequency questionnaires in UK Biobank. We identify 814 associated loci, including olfactory receptor associations with fruit and tea intake; 136 associations are only identified using dietary patterns. Mendelian randomization suggests our top healthful dietary pattern driven by wholemeal vs. white bread consumption is causally influenced by factors correlated with education but is not strongly causal for coronary artery disease or type 2 diabetes. Overall, we demonstra

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • QT prolongation susceptibility discussion Moderate

    rs10504754 A allele interacts with environmental PM exposure to prolong QT interval, a risk factor for cardiac arrhythmias

    discuss air quality sensitivity, baseline cardiac assessment, and arrhythmia risk with cardiologist

Lifestyle

  • reduce particulate matter exposure Moderate

    rs10504754 A allele increases susceptibility to QT interval prolongation during high ambient particulate matter air pollution exposure

    monitor air quality index; use HEPA air filtration indoors on high PM days

Screening

  • baseline electrocardiogram for QT interval assessment Moderate

    rs10504754 A allele is associated with QT prolongation under PM exposure; SNX16 (nearest gene) linked to heart failure

    obtain 12-lead ECG if baseline ECG not available for comparison