rs1050362 - DHX38
Magnitude 2.2 · 1 study on file
Reported associations
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Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease - Unknown journal (n.d.) · Unknown authors · PubMed 29212778
ABSTRACT: Supplemental Digital Content is available in the text. Rationale: Coronary artery disease (CAD) is a complex phenotype driven by genetic and environmental factors. Ninety-seven genetic risk loci have been identified to date, but the identification of additional susceptibility loci might be important to enhance our understanding of the genetic architecture of CAD. Objective: To expand the number of genome-wide significant loci, catalog functional insights, and enhance our understanding of the genetic architecture of CAD. Methods and Results: We performed a genome-wide association study in 34 541 CAD cases and 261 984 controls of UK Biobank resource followed by replication in 88 192 cases and 162 544 controls from CARDIoGRAMplusC4D. We identified 75 loci that replicated and
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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genetic association with coronary artery disease risk Moderate
Variant shows strong GWAS association with CAD, warrants discussion of individual risk factors and prevention
Screening
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cardiovascular risk assessment at younger age Moderate
rs1050362-A associates with coronary artery disease risk in large GWAS (p=3.0e-11, n=547K)
begin baseline cardiovascular screening at age 35-40 if not already done