rs10502431 - ATP7BP1 - RPS4XP18
Magnitude 2.2 · 1 study on file
Reported associations
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Modulation of Genetic Associations with Serum Urate Levels by Body-Mass-Index in Humans - Unknown journal (n.d.) · Unknown authors · PubMed 25811787
ABSTRACT: We tested for interactions between body mass index (BMI) and common genetic variants affecting serum urate levels, genome-wide, in up to 42569 participants. Both stratified genome-wide association (GWAS) analyses, in lean, overweight and obese individuals, and regression-type analyses in a non BMI-stratified overall sample were performed. The former did not uncover any novel locus with a major main effect, but supported modulation of effects for some known and potentially new urate loci. The latter highlighted a SNP at RBFOX3 reaching genome-wide significant level (effect size 0.014, 95% CI 0.008-0.02, Pinter= 2.6 x 10-8). Two top loci in interaction term analyses, RBFOX3 and ERO1LB-EDARADD, also displayed suggestive differences in main effect size between the lean and obese stra
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
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serum urate levels Moderate
Carriers of the C allele show elevated serum urate, a risk factor for gout and kidney disease.
Annual serum urate testing, or sooner if symptoms of gout develop.
Diet
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reduce high-purine foods and fructose Moderate
High-purine diets increase endogenous urate production; genetic predisposition increases susceptibility.
Limit red meat, organ meats, high-fructose foods, and alcohol (especially beer).
Lifestyle
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maintain healthy weight Moderate
The urate-elevating effect of this variant is particularly pronounced in overweight individuals.
If overweight, aim for gradual weight loss through balanced diet and exercise.