Expressive

rs10502386 - MTCL1 - RPS4XP19

Magnitude 2.2 · 1 study on file

Reported associations

  • Novel Genetic Loci Identified for the Pathophysiology of Childhood Obesity in the Hispanic Population - Unknown journal (n.d.) · Unknown authors · PubMed 23251661

    ABSTRACT: Genetic variants responsible for susceptibility to obesity and its comorbidities among Hispanic children have not been identified. The VIVA LA FAMILIA Study was designed to genetically map childhood obesity and associated biological processes in the Hispanic population. A genome-wide association study (GWAS) entailed genotyping 1.1 million single nucleotide polymorphisms (SNPs) using the Illumina Infinium technology in 815 children. Measured genotype analysis was performed between genetic markers and obesity-related traits i.e., anthropometry, body composition, growth, metabolites, hormones, inflammation, diet, energy expenditure, substrate utilization and physical activity. Identified genome-wide significant loci: 1) corroborated genes implicated in other studies (MTNR1B, ZNF259

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Exercise

  • regular aerobic physical activity Moderate

    physical activity counters genetic predisposition to obesity-related traits indicated by rs10502386

    aim for at least 150 minutes of moderate-intensity aerobic activity per week

Lifestyle

  • weight management and dietary counseling Moderate

    genetic predisposition indicated by rs10502386 association with obesity-related traits suggests personalized interventions may be beneficial

    discuss evidence-based weight management approach with healthcare provider or dietitian

Screening

  • weight and BMI monitoring Moderate

    rs10502386 A allele associates with increased obesity-related traits; periodic monitoring enables early intervention

    measure weight and BMI at least annually, more frequently if carrying risk allele