Expressive

rs1050226 - SSR1

Magnitude 2.2 · 2 studies on file

Reported associations

  • Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes - Unknown journal (n.d.) · Unknown authors · PubMed 30054458

    ABSTRACT: Type 2 diabetes (T2D) is a very common disease in humans. Here we conduct a meta-analysis of genome-wide association studies (GWAS) with ~16 million genetic variants in 62,892 T2D cases and 596,424 controls of European ancestry. We identify 139 common and 4 rare variants associated with T2D, 42 of which (39 common and 3 rare variants) are independent of the known variants. Integration of the gene expression data from blood (n = 14,115 and 2765) with the GWAS results identifies 33 putative functional genes for T2D, 3 of which were targeted by approved drugs. A further integration of DNA methylation (n = 1980) and epigenomic annotation data highlight 3 genes (CAMK1D, TP53INP1, and ATP5G1) with plausible regulatory mechanisms, whereby a genetic variant exerts an effect on T2

  • Decreased Circulating Very Small Low-Density Lipoprotein is Likely Causal for Age-Related Macular Degeneration - Unknown journal (n.d.) · Unknown authors · PubMed 39091897

    ABSTRACT: Objective Abnormal changes in metabolite levels in serum or plasma have been highlighted in several studies in age-related macular degeneration (AMD), the leading cause of irreversible vision loss. Specific changes in lipid profiles are associated with an increased risk of AMD. Metabolites could thus be used to investigate AMD disease mechanisms or incorporated into AMD risk prediction models. However, whether particular metabolites causally affect the disease has yet to be established. Design A 3-tiered analysis of blood metabolites in the United Kingdom (UK) Biobank cohort to identify metabolites that differ in AMD patients with evidence for a putatively causal role in AMD. Participants A total of 72 376 donors from the UK Biobank cohort including participants with AMD (N = 

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • Fasting glucose and HbA1c testing Moderate

    G allele at rs1050226 associated with higher fasting glucose levels independent of diagnosed diabetes

    Annual testing; more frequent if HbA1c is in prediabetic range (5.7-6.4%)

Diet

  • Emphasize whole grains over refined carbohydrates Moderate

    Whole grain consumption and low glycemic index diets improve glucose control and reduce diabetes risk

    Replace refined grains with whole grains; limit added sugars to under 10% of calories

Lifestyle

  • Regular aerobic exercise for glucose management Moderate

    Exercise improves insulin sensitivity and glucose control, reducing diabetes progression risk

    150 minutes per week moderate-intensity aerobic activity

Screening

  • Type 2 diabetes risk evaluation Moderate

    rs1050226 G allele strongly associated with type 2 diabetes risk in large cohort

    Discuss screening and prevention strategy with physician