rs10501626 - ME3

Magnitude 2.0 · 1 study on file

Reported associations

• Genome-wide analysis of genetic pleiotropy and causal genes across three age-related ocular disorders. - Human genetics (2023) · Yao X, Yang H, Han H, Kou X, Jiang Y, Luo M, Zhou Y, Wang J, Fan X, Wang X, Li MJ, Yan H · PubMed 36917350

  Age-related macular degeneration (AMD), cataract, and glaucoma are leading causes of blindness worldwide. Previous genome-wide association studies (GWASs) have revealed a variety of susceptible loci associated with age-related ocular disorders, yet the genetic pleiotropy and causal genes across these diseases remain poorly understood. By leveraging large-scale genetic and observational data from ocular disease GWASs and UK Biobank (UKBB), we found significant pairwise genetic correlations and consistent epidemiological associations among these ocular disorders. Cross-disease meta-analysis uncovered seven pleiotropic loci, three of which were replicated in an additional cohort. Integration of variants in pleiotropic loci and multiple single-cell omics data identified that Müller cells and

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