rs10501149 - PRR5L
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-wide association analysis of 350 000 Caucasians from the UK Biobank identifies novel loci for asthma, hay fever and eczema - Unknown journal (n.d.) · Unknown authors · PubMed 31361310
ABSTRACT: Abstract Even though heritability estimates suggest that the risk of asthma, hay fever and eczema is largely due to genetic factors, previous studies have not explained a large part of the genetics behind these diseases. In this genome-wide association study, we include 346 545 Caucasians from the UK Biobank to identify novel loci for asthma, hay fever and eczema and replicate novel loci in three independent cohorts. We further investigate if associated lead single nucleotide polymorphisms (SNPs) have a significantly larger effect for one disease compared to the other diseases, to highlight possible disease-specific effects. We identified 141 loci, of which 41 are novel, to be associated (P ≤ 3 × 10−8) with asthma, hay fever or eczema, analyzed separately or as dis
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Genetic predisposition for hay fever and eczema and prevention strategies Moderate
GWAS evidence supports increased genetic risk; discussion with healthcare provider can guide screening and prevention approaches
Lifestyle
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Allergen avoidance and environmental control strategies Moderate
Genetic predisposition to allergic diseases is mitigated by reduced allergen exposure and environmental optimization
Use HEPA air filters, maintain indoor humidity 40-60%, minimize dust mites and pet dander
Screening
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Screen for hay fever and eczema symptoms Moderate
rs10501149 G allele increases genetic risk for hay fever and eczema; early identification enables timely management