rs10499812 - AUTS2
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-wide association study and trans-ethnic meta-analysis identify novel susceptibility loci for type 2 diabetes mellitus - Unknown journal (n.d.) · Unknown authors · PubMed 38685053
ABSTRACT: Background The genetic basis of type 2 diabetes (T2D) is under-investigated in the Middle East, despite the rapidly growing disease prevalence. We aimed to define the genetic determinants of T2D in Qatar. Methods Using whole genome sequencing of 11,436 participants (2765 T2D cases and 8671 controls) from the population-based Qatar Biobank (QBB), we conducted a genome-wide association study (GWAS) of T2D with and without body mass index (BMI) adjustment. Results We replicated 93 known T2D-associated loci in a BMI-unadjusted model, while 96 known loci were replicated in a BMI-adjusted model. The effect sizes and allele frequencies of replicated SNPs in the Qatari population generally concurred with those from European populations. We identified a locus specific to our cohort locate
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Type 2 diabetes genetic risk Moderate
rs10499812-G increases Type 2 diabetes susceptibility; discussion enables personalized prevention planning
Lifestyle
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weight management and regular physical activity Moderate
lifestyle intervention significantly reduces Type 2 diabetes incidence, even in genetically susceptible individuals
weight management if overweight; 150 minutes moderate aerobic activity per week
Screening
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HbA1c and fasting blood glucose Moderate
rs10499812-G allele is associated with elevated Type 2 diabetes risk; regular monitoring detects early metabolic changes
HbA1c and fasting glucose testing every 1-2 years; increase frequency if prediabetic