rs10499596 - SFRP4

Magnitude 2.2 · 1 study on file

Reported associations

• Intrinsic and extrinsic risk factors for sagging eyelids. - JAMA dermatology (2014) · Jacobs LC, Liu F, Bleyen I, Gunn DA, Hofman A, Klaver CC, Uitterlinden AG, Neumann HA, Bataille V, Spector TD, Kayser M, Nijsten T · PubMed 24869959

  Sagging eyelids, or dermatochalasis, are a frequent concern in older adults. It is considered a feature of skin aging, but risk factors other than aging are largely unknown. To study nongenetic and genetic risk factors for sagging eyelids. Upper eyelid sagging was graded in 4 categories of severity using digital photographs. Dermatochalasis was defined as the eyelid hanging over the eyelashes. Age, sex, skin color, tanning ability, hormonal status in women, current smoking, body mass index, and sun protection behavior were analyzed in a multivariable multinomial logistic regression model. Genetic predisposition was assessed using heritability analysis and a genome-wide association study. The study was performed in 2 independent population-based cohorts. The Rotterdam Study included older a

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