rs10498690 - RNF144B - MIR548A1HG

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-Wide Association Study of Obsessive-Compulsive Symptoms including 33,943 individuals from the general population - Unknown journal (n.d.) · Unknown authors · PubMed 38548983

  ABSTRACT: While 1-2% of individuals meet the criteria for a clinical diagnosis of obsessive-compulsive disorder (OCD), many more (~13-38%) experience subclinical obsessive-compulsive symptoms (OCS) during their life. To characterize the genetic underpinnings of OCS and its genetic relationship to OCD, we conducted the largest genome-wide association study (GWAS) meta-analysis of parent- or self-reported OCS to date (N = 33,943 with complete phenotypic and genome-wide data), combining the results from seven large-scale population-based cohorts from Sweden, the Netherlands, England, and Canada (including six twin cohorts and one cohort of unrelated individuals). We found no genome-wide significant associations at the single-nucleotide polymorphism (SNP) or gene-level, but a polygenic

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