Expressive

rs10498345 - CLEC14A - LINC00639

Magnitude 4.5 · 1 study on file

Reported associations

  • A novel genetic marker for coronary spasm in women from a genome-wide single nucleotide polymorphism analysis. - Pharmacogenetics and genomics (2008) · Suzuki S, Yoshimura M, Nakayama M, Abe K, Yamamuro M, Nagayoshi Y, Kojima S, Kaikita K, Sugiyama S, Yasue H, Ogawa H · PubMed 18075462

    Coronary spasm plays an important role in the pathogenesis of variant angina and also ischemic heart diseases in general, and it is more likely to occur in angiographically normal coronary arteries than in stenotic coronary arteries. We previously found a -786T/C polymorphism in the 5'-flanking region of the endothelial nitric oxide synthase (eNOS) gene and reported that this polymorphism is associated with coronary spasm. We report on an investigation of the genetic factor(s) associated with coronary spasm utilizing a genome-wide case-control study. We recruited 411 consecutive Japanese women (201 with coronary spasm; 210 controls) who were all underwent an acetylcholine provocation test. For single nucleotide polymorphism analysis (SNP), 116,204 SNPs were genotyped for 100 women (50 with

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • Coronary spasm risk and vasospastic angina screening Moderate

    Genetic association with coronary spasm and acetylcholine-induced vasoconstriction

    Schedule cardiology consultation to discuss vasospastic angina risk and screening needs

Exercise

  • Moderate regular exercise, avoid intense exertion Moderate

    Intense physical activity can trigger coronary vasospasm; moderate regular activity is protective

    Aim for 150 minutes weekly of moderate activity; avoid sudden intense exertion

Lifestyle

  • Smoking and potent vasoconstrictors Moderate

    Smoking and stimulants trigger coronary vasoconstriction; variant carriers have heightened vasospastic response

    Complete smoking cessation; limit caffeine; avoid cocaine and sympathomimetics

  • Stress management and relaxation practices Moderate

    Emotional stress is a known coronary vasospasm trigger; variant increases vasoconstrictor response

    Pursue daily stress reduction: meditation, yoga, or therapy; aim for 20-30 minutes

Screening

  • Coronary vasospasm screening with stress testing Moderate

    rs10498345 is associated with increased acetylcholine-induced vasoconstriction and coronary spasm risk

    Discuss with cardiologist about baseline stress testing or coronary imaging