Expressive

rs10497673 - ZSWIM2 - IMPDH1P7

Magnitude 2.2 · 1 study on file

Reported associations

  • GWAS of allometric body-shape indices in UK Biobank identifies loci suggesting associations with morphogenesis, organogenesis, adrenal cell renewal and cancer - Unknown journal (n.d.) · Unknown authors · PubMed 34021172

    ABSTRACT: Genetic studies have examined body-shape measures adjusted for body mass index (BMI), while allometric indices are additionally adjusted for height. We performed the first genome-wide association study of A Body Shape Index (ABSI), Hip Index (HI) and the new Waist-to-Hip Index and compared these with traditional indices, using data from the UK Biobank Resource for 219,872 women and 186,825 men with white British ancestry and Bayesian linear mixed-models (BOLT-LMM). One to two thirds of the loci identified for allometric body-shape indices were novel. Most prominent was rs72959041 variant in RSPO3 gene, expressed in visceral adipose tissue and regulating adrenal cell renewal. Highly ranked were genes related to morphogenesis and organogenesis, previously additionally linked to can

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • Cardiovascular risk assessment and prevention strategy Moderate

    Central adiposity predisposition is a cardiometabolic risk factor; professional assessment appropriate for personalized prevention

Exercise

  • Regular aerobic and resistance exercise Moderate

    Exercise effectively reduces central adiposity; genetic predisposition suggests particular benefit from consistent activity

    Aim for 150+ minutes moderate-intensity aerobic activity weekly; add resistance training 2-3 times weekly

Screening

  • Waist circumference and abdominal adiposity Moderate

    T allele is associated with greater waist circumference adjusted for BMI, indicating predisposition to central fat accumulation

    Measure waist circumference annually; maintain below 94 cm (men) or 80 cm (women)