rs10496265 - CHMP4AP1 - LINC01815

Magnitude 2.0 · 1 study on file

Reported associations

• Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study - BMC medical genetics (2007) · Lunetta KL, D'Agostino RB, Karasik D, Benjamin EJ, Guo CY, Govindaraju R, Kiel DP, Kelly-Hayes M, Massaro JM, Pencina MJ, Seshadri S, Murabito JM · PubMed 17903295

  ABSTRACT: Background Family studies and heritability estimates provide evidence for a genetic contribution to variation in the human life span. Methods We conducted a genome wide association study (Affymetrix 100K SNP GeneChip) for longevity-related traits in a community-based sample. We report on 5 longevity and aging traits in up to 1345 Framingham Study participants from 330 families. Multivariable-adjusted residuals were computed using appropriate models (Cox proportional hazards, logistic, or linear regression) and the residuals from these models were used to test for association with qualifying SNPs (70, 987 autosomal SNPs with genotypic call rate ≥80%, minor allele frequency ≥10%, Hardy-Weinberg test p ≥ 0.001). Results In family-based association test (FBAT) models, 8 SNPs in

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