rs10496166 - LINC01890, LINC01888

Magnitude 2.2 · 1 study on file

Reported associations

• A genome-wide association scan of RR and QT interval duration in three European genetically isolated populations. The EUROSPAN project - Unknown journal (n.d.) · Unknown authors · PubMed 20031603

  ABSTRACT: Background We set out to identify common genetic determinants of the length of RR and QT intervals in 2,325 individuals from isolated European populations. Methods and Results We analyzed heart rate at rest, measured as RR interval, and length of corrected QT interval for association to 318,237 SNPs. RR interval was associated to common variants within GPR133, a G-Protein Coupled Receptor (rs885389, P = 3.9 × 10-8). QT interval was associated to the earlier reported NOS1AP gene (rs2880058, P = 2.00 × 10-10) and to a region on chromosome 13 (rs2478333, P = 4.34 × 10-8), which is 100 kb from the closest known transcript LOC730174 and has previously not been associated with length of QT interval. Conclusion Our results suggested association between RR interval and GPR133 and conf

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.