rs10495332 - SIPA1L2
Magnitude 4.5 · 1 study on file
Reported associations
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Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries - Unknown journal (n.d.) · Unknown authors · PubMed 24556642
ABSTRACT: Dental caries continues to be the most common chronic disease in children today. Despite the substantial involvement of genetics in the process of caries development, the specific genes contributing to dental caries remain largely unknown. We performed separate genome-wide association studies of smooth and pit-and-fissure tooth surface caries experience in the primary dentitions of self-reported white children in two samples from Iowa and rural Appalachia. In total, 1006 children (ages 3-12 years) were included for smooth surface analysis, and 979 children (ages 4-14 years) for pit-and-fissure surface analysis. Associations were tested for more than 1.2 million single nucleotide polymorphisms, either genotyped or imputed. We detected genome-wide significant signals in KPNA4 (p-va
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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frequent sugary foods and beverages Moderate
dietary sugars promote caries formation, especially in individuals with genetic susceptibility
limit sweet foods and drinks to meal times
Lifestyle
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enhanced daily oral hygiene Moderate
mechanical plaque removal reduces caries risk across all genetic backgrounds, especially for those with elevated susceptibility
brush twice daily with fluoride toothpaste and floss daily
Screening
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professional dental examination Moderate
genetic risk for caries is best managed through regular professional surveillance and early intervention
dental visit every 6 months