rs10495106 - U3 - NXNP1

Magnitude 2.2 · 1 study on file

Reported associations

• Novel Genetic Variants for Cartilage Thickness and Hip Osteoarthritis - Unknown journal (n.d.) · Unknown authors · PubMed 27701424

  ABSTRACT: Osteoarthritis is one of the most frequent and disabling diseases of the elderly. Only few genetic variants have been identified for osteoarthritis, which is partly due to large phenotype heterogeneity. To reduce heterogeneity, we here examined cartilage thickness, one of the structural components of joint health. We conducted a genome-wide association study of minimal joint space width (mJSW), a proxy for cartilage thickness, in a discovery set of 13,013 participants from five different cohorts and replication in 8,227 individuals from seven independent cohorts. We identified five genome-wide significant (GWS, P≤5·0×10−8) SNPs annotated to four distinct loci. In addition, we found two additional loci that were significantly replicated, but results of combined meta-analysis

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