Expressive

rs1049481 - CALR

Magnitude 2.2 · 1 study on file

Reported associations

  • Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program - Unknown journal (n.d.) · Unknown authors · PubMed 39024449

    ABSTRACT: INTRODUCTION: Findings from genome-wide association studies (GWASs) have provided foundational knowledge of the genetic basis of disease, facilitating precision approaches for prevention and treatment. Current GWAS results are limited by underrepresentation of individuals from diverse populations, leading to concerns with generalizability regarding our knowledge of the relationships between genes, traits, and disease. The Department of Veterans Affairs (VA) Million Veteran Program (MVP), one of the largest US-based biobanks, addresses this need; 29% of MVP comprises individuals genetically similar to African (AFR), Admixed American (AMR), and East Asian (EAS) reference populations. With over 635,000 participants and more than 44.3M genotyped variants linked with detailed phenotyp

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Refined carbohydrates and added sugars Moderate

    Reducing refined carbohydrate intake mitigates diabetes risk and improves glucose metabolism in genetically susceptible individuals.

    Limit refined grains, sugary beverages, and processed foods; prioritize whole grains, legumes, and complex carbohydrates.

Exercise

  • Regular aerobic and resistance exercise Moderate

    Physical activity improves insulin sensitivity and reduces diabetes risk, particularly important in genetically predisposed individuals.

    150 minutes moderate-intensity aerobic activity per week plus 2 days resistance training.

Lifestyle

  • Maintain healthy body weight (BMI 18.5-24.9) Moderate

    Weight management is critical for diabetes prevention, especially in individuals with genetic risk factors.

    Monitor BMI and waist circumference regularly; maintain target BMI <25 if possible.

Screening

  • Diabetes screening and metabolic monitoring High

    Genetic variant associated with increased diabetes risk (GWAS p=2.0e-19, effect=0.038 per risk allele), warranting closer metabolic surveillance.

    Fasting glucose and HbA1c every 1-2 years; annual if age >40 or additional risk factors present.