rs1049331 - HTRA1
Magnitude 2.8 · 1 study on file
Reported associations
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Identification of Genetic Variants for Risk Prediction and Early Diagnosis of Age-Related Macular Degeneration in the Taiwanese Population - Unknown journal (n.d.) · Unknown authors · PubMed 38542204
ABSTRACT: Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly worldwide. The prevalence and phenotypes of AMD differ among populations, including between people in Taiwan and other regions. We performed a genome-wide association study to identify genetic variants and to develop genetic models to predict the risk of AMD development and progression in the Taiwanese population. In total, 4039 patients with AMD and 16,488 non-AMD controls (aged ≥ 65 years) were included. We identified 31 AMD-associated variants (p < 5 × 10−8) on chromosome 10q26, surrounding PLEKHA1-ARMS2-HTRA1. Two genetic models were constructed using the clump and threshold method. Model 1 included the single nucleotide polymorphism rs11200630 and showed a 1.31-fold increase in the r
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
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Body mass index (maintain BMI <25 kg/m2) Low
Higher BMI is a modifiable AMD risk factor; maintaining healthy weight reduces AMD progression risk in those with genetic predisposition
Target BMI <25 kg/m2 through balanced diet and regular exercise
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Cigarette smoking Moderate
Smoking was associated with 6.95-year earlier AMD diagnosis in study cohort; cessation reduces modifiable AMD risk in HTRA1 carriers
Do not smoke; if currently smoking, quit completely
Screening
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Comprehensive AMD eye screening Moderate
HTRA1 variants on chromosome 10q26 are strongly associated with AMD risk; early detection through regular screening enables timely intervention
Annual comprehensive dilated eye examination starting at age 55-60