rs10492268 - MIR4495 - MIR4303
Magnitude 2.2 · 1 study on file
Reported associations
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GWAS of stool frequency provides insights into gastrointestinal motility and irritable bowel syndrome - Unknown journal (n.d.) · Unknown authors · PubMed 34957435
ABSTRACT: Summary Gut dysmotility is associated with constipation, diarrhea, and functional gastrointestinal disorders like irritable bowel syndrome (IBS), although its molecular underpinnings are poorly characterized. We studied stool frequency (defined by the number of bowel movements per day, based on questionnaire data) as a proxy for gut motility in a GWAS meta-analysis including 167,875 individuals from UK Biobank and four smaller population-based cohorts. We identify 14 loci associated with stool frequency (p ≤ 5.0 × 10−8). Gene set and pathway analyses detected enrichment for genes involved in neurotransmitter/neuropeptide signaling and preferentially expressed in enteric motor neurons controlling peristalsis. PheWAS identified pleiotropic associations with dysmotility syndro
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Screening
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IBS-D symptom monitoring Moderate
T allele at rs10492268 shows strong genetic correlation with IBS-D risk; T allele carriers have substantially elevated predisposition to diarrhea-predominant functional GI disorder
Track bowel frequency and consistency weekly; discuss GI symptoms with doctor if diarrhea patterns persist