rs10492002 - ACSS3

Magnitude 4.5 · 1 study on file

Reported associations

• A Genome-wide Association Study of a Sustained Pattern of Antidepressant Response - Unknown journal (n.d.) · Unknown authors · PubMed 23726668

  ABSTRACT: Genome-wide association studies (GWAS) have failed to replicate common genetic variants associated with antidepressant response, as defined using a single endpoint. Genetic influences may be discernible by examining individual variation between sustained versus unsustained patterns of response, which may distinguish medication effects from non-specific, or placebo responses to active medication. We conducted a GWAS among 1,116 subjects with Major Depressive Disorder from the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial who were characterized using Growth Mixture Modeling as showing a sustained versus unsustained pattern of clinical response over 12 weeks of treatment with citalopram. Replication analyses examined 585 subjects from the Genome-based Therape

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