rs10491678 - LINGO2 - ME2P1
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-Wide Association Study Identification of Novel Loci Associated with Airway Responsiveness in Chronic Obstructive Pulmonary Disease. - American journal of respiratory cell and molecular biology (2015) · Hansel NN, Paré PD, Rafaels N, Sin DD, Sandford A, Daley D, Vergara C, Huang L, Elliott WM, Pascoe CD, Arsenault BA, Postma DS, Boezen HM, Bossé Y, van den Berge M, Hiemstra PS, Cho MH, Litonjua AA, Sparrow D, Ober C, Wise RA, Connett J, Neptune ER, Beaty TH, Ruczinski I, Mathias RA, Barnes KC · PubMed 25514360
Increased airway responsiveness is linked to lung function decline and mortality in subjects with chronic obstructive pulmonary disease (COPD); however, the genetic contribution to airway responsiveness remains largely unknown. A genome-wide association study (GWAS) was performed using the Illumina (San Diego, CA) Human660W-Quad BeadChip on European Americans with COPD from the Lung Health Study. Linear regression models with correlated meta-analyses, including data from baseline (n = 2,814) and Year 5 (n = 2,657), were used to test for common genetic variants associated with airway responsiveness. Genotypic imputation was performed using reference 1000 Genomes Project data. Expression quantitative trait loci (eQTL) analyses in lung tissues were assessed for the top 10 markers iden
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
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smoking and occupational respiratory irritants Moderate
C allele carriers have heightened airway responsiveness; smoking and occupational exposures would exacerbate this trait and increase COPD risk.
Avoid smoking completely; use respiratory protection when exposed to workplace dust, fumes, or chemical irritants.
Screening
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COPD risk assessment and pulmonary function testing Moderate
rs10491678 C allele is associated with increased airway responsiveness in COPD, a physiological trait linked to obstructive airway disease.
Discuss baseline pulmonary function testing (spirometry) with physician if carrying risk allele.