rs10491424 - WDR36
Magnitude 2.2 · 1 study on file
Reported associations
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Discerning asthma endotypes through comorbidity mapping - Unknown journal (n.d.) · Unknown authors · PubMed 36344522
ABSTRACT: Asthma is a heterogeneous, complex syndrome, and identifying asthma endotypes has been challenging. We hypothesize that distinct endotypes of asthma arise in disparate genetic variation and life-time environmental exposure backgrounds, and that disease comorbidity patterns serve as a surrogate for such genetic and exposure variations. Here, we computationally discover 22 distinct comorbid disease patterns among individuals with asthma (asthma comorbidity subgroups) using diagnosis records for >151 M US residents, and re-identify 11 of the 22 subgroups in the much smaller UK Biobank. GWASs to discern asthma risk loci for individuals within each subgroup and in all subgroups combined reveal 109 independent risk loci, of which 52 are replicated in multi-ancestry meta-analysis acro
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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asthma genetic risk and preventive management strategy Moderate
Genetic predisposition warrants clinical assessment and personalized prevention planning
review findings with healthcare provider; establish baseline asthma risk assessment
Screening
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allergic sensitization and IgE testing Moderate
TSLP promotes Th2 differentiation and allergic inflammation in asthma pathogenesis
baseline serum IgE and allergen-specific IgE panel
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pulmonary function and asthma symptoms Moderate
WDR36 C allele increases asthma susceptibility through TSLP-mediated Th2 immune response
baseline spirometry or peak flow testing; annual reassessment if risk confirmed