Expressive

rs10491083 - C17orf100

Magnitude 4.5 · 1 study on file

Reported associations

  • Genetic Variants in the Bone Morphogenic Protein Gene Family Modify the Association between Residential Exposure to Traffic and Peripheral Arterial Disease - Unknown journal (n.d.) · Unknown authors · PubMed 27082954

    ABSTRACT: There is a growing literature indicating that genetic variants modify many of the associations between environmental exposures and clinical outcomes, potentially by increasing susceptibility to these exposures. However, genome-scale investigations of these interactions have been rarely performed particularly in the case of air pollution exposures. We performed race-stratified genome-wide gene-environment interaction association studies on European-American (EA, N = 1623) and African-American (AA, N = 554) cohorts to investigate the joint influence of common single nucleotide polymorphisms (SNPs) and residential exposure to traffic ("traffic exposure")-a recognized vascular disease risk factor-on peripheral arterial disease (PAD). Traffic exposure was estimated via the dis

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Lifestyle

  • High-traffic air pollution exposure Moderate

    This variant increases peripheral arterial disease risk when combined with traffic-related air pollution exposure

    Reduce time in high-traffic areas; use air filtration; check air quality before outdoor activities

Screening

  • Cardiovascular health status Moderate

    Carriers of this variant have elevated peripheral arterial disease risk requiring ongoing vascular monitoring

    Regular cardiovascular check-ups; maintain healthy blood pressure and lipid levels

  • Peripheral arterial disease screening Moderate

    This variant is associated with increased peripheral arterial disease risk, particularly with air pollution exposure

    Discuss with doctor about vascular assessment such as ankle-brachial index testing