rs10490625 - INSIG2
Magnitude 2.2 · 1 study on file
Reported associations
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Genetics of 35 blood and urine biomarkers in the UK Biobank - Unknown journal (n.d.) · Unknown authors · PubMed 33462484
ABSTRACT: Clinical laboratory tests are a critical component of the continuum of care. We evaluate the genetic basis of 35 blood and urine laboratory measurements in the UK Biobank (n=363,228 individuals). We identify 1,857 loci associated with at least one trait, containing 3,374 fine-mapped associations, and additional sets of large-effect (> 0.1 sd) protein-altering, HLA, and copy-number variant associations. Through Mendelian Randomization analysis, we discover 51 causal relationships, including previously known agonistic effects of urate on gout and cystatin C on stroke. Finally, we develop polygenic risk scores for each biomarker and built 'multi-PRS' models for diseases using 35 PRSs simultaneously, which improved chronic kidney disease, type 2 diabetes, gout, and alcoholic cirr
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
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lipid panel screening High
The rs10490625 A allele is strongly associated with elevated LDL cholesterol (p=2.0e-23) and total cholesterol (p=3.0e-21)
Baseline lipid panel, then annually or as recommended based on results
Diet
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heart-healthy dietary pattern for cholesterol management Moderate
Genetic elevation of cholesterol can be partially moderated through dietary reduction of saturated fat and increased plant sterol intake
Emphasize whole grains, fruits, vegetables, and limit saturated fat to less than 7% of daily calories
Discuss with your doctor
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lipid management and cardiovascular risk strategy High
Genetic variants affecting cholesterol metabolism warrant personalized lipid assessment and cardiovascular risk evaluation