rs10490528 - GALNT13
Magnitude 2.2 · 1 study on file
Reported associations
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Trans-ancestry analysis reveals genetic and nongenetic associations with COVID-19 susceptibility and severity. - Nature genetics (2021) · Shelton JF, Shastri AJ, Ye C, Weldon CH, Filshtein-Sonmez T, Coker D, Symons A, Esparza-Gordillo J, Aslibekyan S, Auton A · PubMed 33888907
COVID-19 presents with a wide range of severity, from asymptomatic in some individuals to fatal in others. Based on a study of 1,051,032 23andMe research participants, we report genetic and nongenetic associations with testing positive for SARS-CoV-2, respiratory symptoms and hospitalization. Using trans-ancestry genome-wide association studies, we identified a strong association between blood type and COVID-19 diagnosis, as well as a gene-rich locus on chromosome 3p21.31 that is more strongly associated with outcome severity. Hospitalization risk factors include advancing age, male sex, obesity, lower socioeconomic status, non-European ancestry and preexisting cardiometabolic conditions. While non-European ancestry was a significant risk factor for hospitalization after adjusting for soci
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Early COVID-19 treatment strategy Moderate
Genetic variants in GALNT13 increase pneumonia severity risk and may benefit from early intervention strategies.
Discuss early antiviral or monoclonal antibody therapy if COVID-19 symptoms develop
Screening
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Ensure COVID-19 vaccination up-to-date Moderate
GALNT13 rs10490528 is associated with severe COVID-19 pneumonia susceptibility in large-scale studies.
Maintain current COVID-19 vaccination status with recommended boosters