rs1048990 - PSMA6
Magnitude 2.2 · 1 study on file
Reported associations
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Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology - Unknown journal (n.d.) · Unknown authors · PubMed 29083406
ABSTRACT: Asthma, hay fever (or allergic rhinitis) and eczema (or atopic dermatitis) often coexist in the same individuals, partly because of a shared genetic origin. To identify shared risk variants, we performed a genome-wide association study (GWAS, n=360,838) of a broad allergic disease phenotype that considers the presence of any one of these three diseases. We identified 136 independent risk variants (P<3x10-8), including 73 not previously reported, which implicate 132 nearby genes in allergic disease pathophysiology. Disease-specific effects were detected for only six variants, confirming that most represent shared risk factors. Tissue-specific heritability and biological process enrichment analyses suggest that shared risk variants influence lymphocyte-mediated immunity. Six target
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Personalized allergy prevention strategy Moderate
Genetic predisposition to allergic disease warrants individualized clinical guidance on preventive approaches
Schedule discussion with primary care or allergist
Lifestyle
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Allergen minimization and environmental control Moderate
Reducing exposure to common allergens benefits individuals with genetic predisposition to allergic disease
Use HEPA filtration, minimize dust and pet exposure, identify and avoid personal triggers
Screening
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Allergic disease screening Moderate
Variant increases risk for asthma, hay fever, and eczema; early detection enables timely management
Baseline screening by age 25; repeat if symptomatic