rs10489744 - RXRG

Magnitude 2.0 · 1 study on file

Reported associations

• Genetic overlap between Attention-Deficit/Hyperactivity Disorder and Bipolar Disorder: Evidence from GWAS meta-analysis. - Unknown journal (n.d.) · Unknown authors · PubMed 27890468

  ABSTRACT: Background: Attention-deficit/hyperactivity disorder (ADHD) and bipolar disorder (BPD) are frequently co-occurring and highly heritable mental health conditions. We hypothesized that BPD cases with an early age of onset (≤21 years) would be particularly likely to show genetic covariation with ADHD. Methods: GWAS data were available for 4,609 individuals with ADHD, 9,650 individuals with BPD (5,167 thereof with early-onset BPD) and 21,363 typically developing controls. We conducted a cross-disorder GWAS meta-analysis to identify whether the observed comorbidity between ADHD and BPD could be due to shared genetic risks. Results: We found a significant SNP-based genetic correlation between ADHD and BPD in the full and age-restricted samples (rGfull = 0.64, p = 3.13×10−14; rGres

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