rs10488698 - BUD13
Magnitude 2.2 · 1 study on file
Reported associations
-
A Genome-Wide Association Study of Metabolic Syndrome in the Taiwanese Population - Unknown journal (n.d.) · Unknown authors · PubMed 38201907
ABSTRACT: The purpose of this study was to investigate genetic factors associated with metabolic syndrome (MetS) by conducting a large-scale genome-wide association study (GWAS) in Taiwan, addressing the limited data on Asian populations compared to Western populations. Using data from the Taiwan Biobank, comprehensive clinical and genetic information from 107,230 Taiwanese individuals was analyzed. Genotyping data from the TWB1.0 and TWB2.0 chips, including over 650,000 single nucleotide polymorphisms (SNPs), were utilized. Genotype imputation using the 1000 Genomes Project was performed, resulting in more than 9 million SNPs. MetS was defined based on a modified version of the Adult Treatment Panel III criteria. Among all participants (mean age: 50 years), 23% met the MetS definition. GW
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
-
Metabolic syndrome risk and family screening history Moderate
The G allele at rs10488698 is associated with increased metabolic syndrome risk in a large GWAS study (p=2.00e-9), suggesting elevated genetic predisposition.
Screening
-
Metabolic syndrome screening Moderate
G allele carriers show increased metabolic syndrome risk; early identification enables preventive management of blood pressure, lipids, and glucose.
Measure waist circumference, blood pressure, fasting triglycerides, fasting glucose, and HDL cholesterol; repeat annually or per physician guidance