Expressive

rs10486776 - LINC02587

Magnitude 4.5 · 1 study on file

Reported associations

  • A genome-wide genotyping study in patients with ischaemic stroke: initial analysis and data release. - The Lancet. Neurology (2007) · Matarín M, Brown WM, Scholz S, Simón-Sánchez J, Fung HC, Hernandez D, Gibbs JR, De Vrieze FW, Crews C, Britton A, Langefeld CD, Brott TG, Brown RD, Worrall BB, Frankel M, Silliman S, Case LD, Singleton A, Hardy JA, Rich SS, Meschia JF · PubMed 17434096

    Despite evidence of a genetic role in stroke, the identification of common genetic risk factors for this devastating disorder remains problematic. We aimed to identify any common genetic variability exerting a moderate to large effect on risk of ischaemic stroke, and to generate publicly available genome-wide genotype data to facilitate others doing the same. We applied a genome-wide high-density single-nucleotide-polymorphism (SNP) genotyping approach to a cohort of samples with and without ischaemic stroke (n=278 and 275, respectively), and did an association analysis adjusted for known confounders in a final cohort of 249 cases and 268 controls. More than 400,000 unique SNPs were assayed. We produced more than 200 million genotypes in 553 unique participants. The raw genotypes of all th

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • stroke risk assessment and prevention strategy Moderate

    Genetic predisposition to stroke warrants formal risk assessment and discussion of personalized prevention strategies with healthcare provider.

Exercise

  • regular aerobic exercise Moderate

    Aerobic exercise reduces stroke risk through improved vascular endothelial function, blood pressure regulation, and overall cardiovascular fitness.

    150 minutes per week of moderate-intensity aerobic activity or 75 minutes vigorous intensity

Screening

  • blood pressure and cardiovascular screening Moderate

    Genetic association with stroke risk indicates benefit of proactive monitoring of key modifiable stroke risk factors, particularly blood pressure.

    Baseline blood pressure assessment and annual monitoring; home monitoring if readings are elevated