rs10486607 - CPVL

Magnitude 2.0 · 1 study on file

Reported associations

• Genome-wide association with diabetes-related traits in the Framingham Heart Study - BMC medical genetics (2007) · Meigs JB, Manning AK, Fox CS, Florez JC, Liu C, Cupples LA, Dupuis J · PubMed 17903298

  ABSTRACT: Background Susceptibility to type 2 diabetes may be conferred by genetic variants having modest effects on risk. Genome-wide fixed marker arrays offer a novel approach to detect these variants. Methods We used the Affymetrix 100K SNP array in 1,087 Framingham Offspring Study family members to examine genetic associations with three diabetes-related quantitative glucose traits (fasting plasma glucose (FPG), hemoglobin A1c, 28-yr time-averaged FPG (tFPG)), three insulin traits (fasting insulin, HOMA-insulin resistance, and 0-120 min insulin sensitivity index); and with risk for diabetes. We used additive generalized estimating equations (GEE) and family-based association test (FBAT) models to test associations of SNP genotypes with sex-age-age2-adjusted residual trait values, and

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