rs10485681 - RNU6-1018P - NEFHP2

Magnitude 2.0 · 1 study on file

Reported associations

• Genetic risk factors for decreased bone mineral accretion in children with asthma receiving multiple oral corticosteroid bursts - Unknown journal (n.d.) · Unknown authors · PubMed 26025128

  ABSTRACT: Introduction Long-term, intermittent oral corticosteroid (OCS) use in children with asthma leads to significant decrements in bone mineral accretion (BMA). We aimed to identify genetic factors influencing OCS dose effects on BMA in children with asthma. Methods We first performed a gene by OCS interaction genome-wide association study (GWAS) of BMA in 489 white participants in the Childhood Asthma Management Program trial, who took short-term oral prednisone bursts when they experienced acute asthma exacerbations. We selected the top-ranked 2,000 single nucleotide polymorphisms (SNPs) in the GWAS and determined whether these SNPs also had cis-regulatory effects on dexamethasone-induced gene expression in osteoblast cells. Results We identified two SNPs (rs9896933 and rs2074439) a

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