Expressive

rs10483282 - BRD7P1 - RN7SKP205

Magnitude 2.8 · 1 study on file

Reported associations

  • Genome-wide association study of alcohol dependence: significant findings in African- and European-Americans including novel risk loci - Unknown journal (n.d.) · Unknown authors · PubMed 24166409

    ABSTRACT: We report a GWAS of alcohol dependence (AD) in European-American (EA) and African-American (AA) populations, with replication in independent samples of EAs, AAs and Germans. Our sample for discovery and replication was 16 087 subjects, the largest sample for AD GWAS to date. Numerous genome-wide significant (GWS) associations were identified, many novel. Most associations were population specific, but in several cases were GWS in EAs and AAs for different SNPs at the same locus, showing biological convergence across populations. We confirmed well-known risk loci mapped to alcohol-metabolizing enzyme genes, notably ADH1B (EAs: Arg48His, P = 1.17 × 10−31; AAs: Arg369Cys, P = 6.33 × 10−17) and ADH1C in AAs (Thr151Thr, P = 4.94 × 10−10), and identified novel risk loci mappin

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • discuss alcohol dependence genetic risk with provider Moderate

    rs10483282 T allele shows GWAS association with alcohol dependence risk; healthcare provider can assess personal risk factors and recommend interventions

    discuss personal and family history of alcohol use during health visit

Lifestyle

  • limit alcohol consumption to reduce dependence risk Moderate

    Genetic predisposition increases susceptibility; behavioral modulation (limiting exposure) can reduce risk manifestation

    follow medical guidelines for safe alcohol consumption; consider abstinence given genetic risk

Screening

  • monitor for alcohol dependence symptoms and use patterns Moderate

    Genetic predisposition to alcohol dependence warrants monitoring for early signs of problematic use; early detection enables intervention

    assess alcohol use frequency, quantity, and functional impacts; seek professional screening if concerning patterns emerge