rs1048040 - DDX6
Magnitude 2.2 · 1 study on file
Reported associations
-
The genetic basis of dermatophytosis skin infection susceptibility - Unknown journal (n.d.) · Unknown authors · PubMed 41792138
ABSTRACT: Dermatophytosis is a fungal infection affecting keratinized tissues such as skin, nails, and hair, presenting as red and itchy patches, nail thickening, or hair loss. It affects around 20% of the global population but the genetic architecture remains poorly understood. We performed a genome-wide association meta-analysis of over 250,000 cases and 1.37 million controls from FinnGen, Estonian Biobank, UK Biobank, and the Million Veteran Program and identified 30 genome-wide significant loci, including seven missense variants and two loci in high linkage disequilibrium with missense variants. Top associations were near ZNF646, HLA-DQB1, FLG, FTO, SLURP2, and KRT77. Additionally, dermatophytosis subtype analyses revealed 44 signals. Our results highlight the role of disrupted keratin
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
-
tinea unguium genetic risk discussion Moderate
rs1048040 G allele increases tinea unguium risk; discussion can guide preventive strategies.
Lifestyle
-
nail and foot hygiene for infection prevention Moderate
Preventive measures reduce tinea unguium risk in individuals with genetic susceptibility.
Keep nails trimmed short, maintain dry feet, wear breathable footwear, avoid nail trauma.
Screening
-
fungal nail infection (tinea unguium) screening Moderate
rs1048040 G allele is associated with increased tinea unguium susceptibility in large GWAS study.
Annual foot and nail examination for signs of discoloration, thickening, or crumbling.