Expressive

rs1047995186 - U3 - NXNP1

Magnitude 2.2 · 1 study on file

Reported associations

  • Ancestry- and sex-specific effects underlying inguinal hernia susceptibility identified in a multiethnic genome-wide association study meta-analysis - Unknown journal (n.d.) · Unknown authors · PubMed 35022708

    ABSTRACT: Abstract Inguinal hernias are some of the most frequently diagnosed conditions in clinical practice and inguinal hernia repair is the most common procedure performed by general surgeons. Studies of inguinal hernias in non-European populations are lacking, though it is expected that such studies could identify novel loci. Further, the cumulative lifetime incidence of inguinal hernia is nine times greater in men than women, however, it is not clear why this difference exists. We conducted a genome-wide association meta-analysis of inguinal hernia risk across 513 120 individuals (35 774 cases and 477 346 controls) of Hispanic/Latino, African, Asian and European descent, with replication in 728 418 participants (33 491 cases and 694 927 controls) from the 23andMe, Inc dat

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • Genetic inguinal hernia risk counseling Moderate

    Increased genetic susceptibility warrants clinical counseling on symptoms, prevention, and when to seek care

Lifestyle

  • Heavy lifting and excessive straining Moderate

    Abdominal wall tension from heavy lifting increases hernia risk; genetic variant compounds this susceptibility

    Avoid lifting greater than 25 lbs without proper support; use proper body mechanics

  • Maintain healthy BMI Moderate

    Excess abdominal weight increases intra-abdominal pressure, compounding genetic hernia risk

    Target BMI 18.5-24.9 through balanced diet and regular exercise

Screening

  • Inguinal hernia screening in adulthood Moderate

    Genetic variant increases inguinal hernia risk 1.067-fold; early detection enables timely intervention