rs10476160 - SFXN1 - RN7SKP148 x RPL23AP54 - RN7SKP159

Magnitude 4.5 · 1 study on file

Reported associations

• A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis - Unknown journal (n.d.) · Unknown authors · PubMed 23509962

  ABSTRACT: Background Venous Thrombosis (VT) is a common multifactorial disease with an estimated heritability between 35% and 60%. Known genetic polymorphisms identified so far only explain ~5% of the genetic variance of the disease. This study was aimed to investigate whether pair-wise interactions between common single nucleotide polymorphisms (SNPs) could exist and modulate the risk of VT. Methods A genome-wide SNP x SNP interaction analysis on VT risk was conducted in a French case-control study and the most significant findings were tested for replication in a second independent French case-control sample. The results obtained in the two studies totaling 1,953 cases and 2,338 healthy subjects were combined into a meta-analysis. Results The smallest observed p-value for interaction

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