rs10475978 - FGF18

Magnitude 2.2 · 1 study on file

Reported associations

• Insight into the genetic architecture of back pain and its risk factors from a study of 509,000 individuals - Unknown journal (n.d.) · Unknown authors · PubMed 30747904

  ABSTRACT: Back pain (BP) is a common condition of major social importance and poorly understood pathogenesis. Combining data from the UK Biobank and CHARGE consortium cohorts allowed us to perform a very large GWAS (total N = 509,070) and examine the genetic correlation and pleiotropy between BP and its clinical and psychosocial risk factors. We identified and replicated three BP associated loci, including one novel region implicating SPOCK2/CHST3 genes. We provide evidence for pleiotropic effects of genetic factors underlying BP, height, and intervertebral disc problems. We also identified independent genetic correlations between BP and depression symptoms, neuroticism, sleep disturbance, overweight, and smoking. A significant enrichment for genes involved in central nervous system and sk

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