rs10475950 - KCNIP1-AS1, KCNIP1

Magnitude 2.2 · 1 study on file

Reported associations

• Association between genes regulating neural pathways for quantitative traits of speech and language disorders - Unknown journal (n.d.) · Unknown authors · PubMed 34315907

  ABSTRACT: Speech sound disorders (SSD) manifest as difficulties in phonological memory and awareness, oral motor function, language, vocabulary, reading, and spelling. Families enriched for SSD are rare, and typically display a cluster of deficits. We conducted a genome-wide association study (GWAS) in 435 children from 148 families in the Cleveland Family Speech and Reading study (CFSRS), examining 16 variables representing 6 domains. Replication was conducted using the Avon Longitudinal Study of Parents and Children (ALSPAC). We identified 18 significant loci (combined p < 10−8) that we pursued bioinformatically. We prioritized 5 novel gene regions with likely functional repercussions on neural pathways, including those which colocalized with differentially methylated regions in ou

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