rs10474356 - ARRDC3-AS1

Magnitude 4.5 · 1 study on file

Reported associations

• Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes - Unknown journal (n.d.) · Unknown authors · PubMed 30279459

  ABSTRACT: The hippocampus is a heterogeneous structure, comprising histologically distinguishable subfields. These subfields are differentially involved in memory consolidation, spatial navigation and pattern separation, complex functions often impaired in individuals with brain disorders characterized by reduced hippocampal volume, including Alzheimer's disease (AD) and schizophrenia. Given the structural and functional heterogeneity of the hippocampal formation, we sought to characterize the subfields' genetic architecture. T1-weighted brain scans (n = 21,297, 16 cohorts) were processed with the hippocampal subfields algorithm in FreeSurfer v6.0. We ran a genome-wide association analysis on each subfield, co-varying for whole hippocampal volume. We further calculated the single-n

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