rs10471966 - IL6ST-DT - ANKRD55

Magnitude 2.0 · 1 study on file

Reported associations

• Genome-wide association study of maternal genetic effects and parent-of-origin effects on food allergy - Unknown journal (n.d.) · Unknown authors · PubMed 29489655

  ABSTRACT: Supplemental Digital Content is available in the text Abstract Previous genetic studies of food allergy (FA) have mainly focused on inherited genotypic effects. The role of parental genotypic effects remains largely unexplored. Leveraging existing genome-wide association study (GWAS) data generated from the Chicago Food Allergy Study, we examined maternal genotypic and parent-of-origin (PO) effects using multinomial likelihood ratio tests in 588 complete and incomplete Caucasian FA trios. We identified 1 single nucleotide polymorphism with significant (P < 5×10−8) maternal effect on any FA (rs4235235), which is located in a noncoding RNA (LOC101927947) with unknown function. We also identified 3 suggestive (P < 5×10−7) loci with maternal genetic effects: 1 for any F

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