Expressive

rs10471048 - SCD5

Magnitude 2.2 · 2 studies on file

Reported associations

  • Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation - Unknown journal (n.d.) · Unknown authors · PubMed 35551307

    ABSTRACT: We assembled an ancestrally diverse collection of genome-wide association studies (GWAS) of type 2 diabetes (T2D) in 180,834 cases and 1,159,055 controls (48.9% non-European descent) through the DIAMANTE (DIAbetes Meta-ANalysis of Trans-Ethnic association studies) Consortium. Multi-ancestry GWAS meta-analysis identified 237 loci attaining stringent genome-wide significance (P < 5 x 10−9), which were delineated to 338 distinct association signals. Fine-mapping of these signals was enhanced by the increased sample size and expanded population diversity of the multi-ancestry meta-analysis, which localized 54.4% of T2D associations to a single variant with >50% posterior probability. This improved fine-mapping enabled systematic assessment of candidate causal genes and molecular me

  • Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ethnic meta-analysis - Unknown journal (n.d.) · Unknown authors · PubMed 32541925

    ABSTRACT: We investigated type 2 diabetes (T2D) genetic susceptibility via multi-ethnic meta-analysis of 228,499 cases and 1,178,783 controls in the Million Veteran Program, DIAMANTE, Biobank Japan, and other studies. We report 568 associations, including 286 autosomal, 7 X chromosomal, and 25 identified in ancestry-specific analyses that were previously unreported. Transcriptome-wide association analysis detected 3,568 T2D-associations with genetically predicted gene expression in 687 novel genes; of these, 54 are known to interact with FDA-approved drugs. A polygenic risk score was strongly associated with increased risk of T2D-related retinopathy and modestly associated with chronic kidney disease (CKD), peripheral artery disease (PAD), and neuropathy. We investigated the genetic etiolo

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Minimize refined carbohydrates and added sugars Moderate

    Reducing glycemic load helps maintain stable glucose levels and mitigates Type 2 diabetes risk in carriers of genetic risk alleles

    Emphasize whole grains, legumes, non-starchy vegetables; limit sweetened beverages

Discuss with your doctor

  • Genetic Type 2 diabetes risk and personalized screening strategy Moderate

    Clinical consultation enables individualized risk assessment and preventive management tailored to genetic predisposition and other clinical factors

Exercise

  • Regular aerobic physical activity Moderate

    Physical activity improves insulin sensitivity and glucose control, reducing Type 2 diabetes progression risk in genetically susceptible individuals

    150 minutes moderate-intensity per week

Screening

  • Type 2 diabetes screening Moderate

    Genetic variants in SCD5 are associated with increased Type 2 diabetes risk through altered lipid metabolism and glucose homeostasis

    Baseline HbA1c and fasting glucose; repeat annually